Anionic Stereogenic-at-Cobalt(III) Complex-Enabled Asymmetric Oxidation of N,N-Dialkyl Sulfenamides

• DOI: 10.1021/acs.orglett.4c04857
• Publication Date: 2025-02-26T13:33:21Z
• Authors: Yue Shen; Xiao-Bao Wu; Hua-Jie Jiang; Liu-Zhu Gong
• Keywords: Stereocenter

An asymmetric oxidation of N,N-dialkyl sulfenamides is exhibited by using anionic stereogenic-at-cobalt(III) complexes as catalysts. This protocol provides an alternative approach to access a diverse set chiral tertiary sulfinamides with high enantioselectivities (24 examples, up 94:6 e.r.). Additionally, control experiments suggest that this could be accomplished through cationic S(IV) intermediate.