(±)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis

• DOI: 10.1021/acs.orglett.5b00448
• Publication Date: 2015-03-06T20:51:40Z
• Authors: Qi Luo; Lei Tian; Lei Di; Yong-Ming Yan; Xiao-Yi Wei; Xin-Fang Wang; Yong-Xian Cheng
• Keywords: Stereocenter

(+)- and (−)-Sinensilactam A (1), novel hybrid metabolites possessing a unique 2H-pyrrolo[2,1-b][1,3]oxazin-6(7H)-one ring system, were isolated from the fruit bodies of Ganoderma sinensis. The structures these substances absolute configurations at their stereocenters assigned using spectroscopic computational methods along with X-ray crystallographic analysis. plausible pathway for biosynthesis 1 is proposed. (−)-1 was found to be Smad3 phosphorylation inhibitor in TGF-β1 induced human renal proximal tubular cells.