Highly Enantioselective [3 + 2]-Annulation of Isatin-Derived Morita–Baylis–Hillman Adducts with Cyclic Sulfonimines

• DOI: 10.1021/acs.orglett.5b00456
• Publication Date: 2015-03-17T14:32:12Z
• Authors: Feng Wei; Hong-Yan Huang; Neng-Jun Zhong; Chun-Ling Gu; Dong Wang; Li Liu
• Keywords: Isatin; Molecular Structure; Stereoisomerism; Sulfhydryl Compounds; 01 natural sciences; Catalysis; 0104 chemical sciences

AbstractThe scalable reaction provides substituted aza‐spirooxindole derivatives containing fused cyclic sultams in a highly diastereoselective and enantioselective manner.