A Concise Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 8

• DOI: 10.1021/acs.orglett.5b00899
• Publication Date: 2015-04-30T15:05:21Z
• Authors: Satsawat Visansir...; Jagodige P. Yasom...; Papapida Pornsuri...; Medha N. Kamat; Nikita M. Podvalnyy; Chase P. Gobble; Melissa Thompson; Stephen A. Kolodziej; Alexei V. Demchenko
• Keywords: Staphylococcus aureus; Carbohydrate Sequence; Polysaccharides, Bacterial; Carbohydrate Conformation; 01 natural sciences; 0104 chemical sciences; 3. Good health

The first synthesis of the repeating unit of S. aureus capsular polysaccharide type 8 is described. The repeating unit is an unusual trisaccharide sequence of three uncommon sugars, all connected via 1,2-cis linkages. The synthetic trisaccharide was equipped with capping methyl groups at the points of propagation of the polysaccharide sequence.