Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines

• DOI: 10.1021/acs.orglett.5b01057
• Publication Date: 2015-06-03T11:25:49Z
• Authors: Ying Chen; Jinkun Huang; Tsang-Lin Hwang; Maosheng J. Chen; Jason S. Tedrow; Robert P. Farrell; Matthew M. Bio; Sheng Cui
• Keywords: Pyridine-N-oxide; Reaction conditions

A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.