Aldehyde as a Traceless Directing Group for Rh(III)-Catalyzed C–H Activation: A Facile Access to Diverse Indolo[1,2-a]quinolines

• DOI: 10.1021/acs.orglett.5b01171
• Publication Date: 2015-05-29T19:16:30Z
• Authors: Xingyan Liu; Xiaoyu Li; Hu Liu; Qiang Guo; Jingbo Lan; Ruilin Wang; Jingsong You
• Keywords: Quinoline

The aldehyde group has been developed for the first time as a traceless directing to promote regioselective Rh(III)-catalyzed C–H activation/cyclization of indolyl aldehydes with alkynes. This protocol streamlines access variety appealing indolo[1,2-a]quinoline structures. As illustrative examples, concise three-step synthesis indolo[1,2-a]quinoline-based sensitizers is accomplished that exhibits potential activation in construction organic optoelectronic materials.