Copper(II)-Catalyzed Direct Sulfonylation of C(sp2)–H Bonds with Sodium Sulfinates

• DOI: 10.1021/acs.orglett.5b01198
• Publication Date: 2015-05-20T15:29:42Z
• Authors: Wei-Hao Rao; Bing-Feng Shi
• Keywords: Ions; Molecular Structure; Sulfonium Compounds; Hydrogen Bonding; 01 natural sciences; Catalysis; 0104 chemical sciences; Benzamides; Sulfones; Copper

A copper-catalyzed direct sulfonylation of C(sp(2))-H bonds with sodium sulfinates using a removable directing group is described. This reaction tolerates a wide range of functional groups, providing an efficient protocol for the synthesis of diverse aryl sulfones. Moreover, a series of 2,6-disubstituted benzamides could be synthesized via sequential C-H functionalization.