Rh(III)-Catalyzed Direct Coupling of Azobenzenes with α-Diazo Esters: Facile Synthesis of Cinnolin-3(2H)-ones

• DOI: 10.1021/acs.orglett.5b01298
• Publication Date: 2015-05-20T11:33:44Z
• Authors: Satyasheel Sharma; Sang Hoon Han; Sangil Han; Wontae Ji; Jongchan Oh; Seok-Yong Lee; Joa Sub Oh; Young Hoon Jung; In Su Kim
• Keywords: Surface Modification; Derivative (finance)

The rhodium(III)-catalyzed direct C–H functionalization of azobenzenes with α-diazo compounds is described. These transformations provide the facile and efficient construction C2-alkylated or highly substituted cinnolin-3(2H)-ones. Furthermore, this protocol leads to formation cinnolin-3(2H)-ones using a diazo derivative Meldrum’s acid.