Stereoselective Synthesis of 3-Carboxy-4,5-dihydropyrroles via an Intramolecular Iminium Ion Cyclization Reaction

• DOI: 10.1021/acs.orglett.5b01787
• Publication Date: 2015-07-27T15:11:39Z
• Authors: Jinbao Xiang; Hongxiang Xie; Zhuo Li; Qun Dang; Xu Bai
• Keywords: Iminium

An efficient and practical method has been developed for the synthesis of trans-4,5-disubstituted 3-carboxy-4,5-dihydropyrroles via an intramolecular iminium ion cyclization reaction readily accessible Baylis-Hillman derivatives aldehydes in moderate to high yield. These new dihydropyrroles could be easily converted pyrroles or pyrrolidines.