Transition-Metal-Free Tandem Chlorocyclization of Amines with Carboxylic Acids: Access to Chloroimidazo[1,2-α]pyridines

• DOI: 10.1021/acs.orglett.5b01868
• Publication Date: 2015-07-31T16:42:56Z
• Authors: Xinsheng Xiao; Ying Xie; Siyi Bai; Yuanfu Deng; Huanfeng Jiang; Wei Zeng
• Keywords: Tandem; Aminopyridines; Cascade reaction

An efficient one-pot and transition-metal-free chlorocyclization cascade of 2-aminopyridines with aliphatic carboxylic acids is reported. This transformation provides a novel approach to 2-chloro- or 3-chloro-substituted imidazo[1, 2-α]pyridines broad range substrate scopes.