I2-Catalyzed C–O Bond Formation and Dehydrogenation: Facile Synthesis of Oxazolines and Oxazoles Controlled by Bases

• DOI: 10.1021/acs.orglett.5b01933
• Publication Date: 2015-07-30T16:25:39Z
• Authors: Wen-Chao Gao; Fei Hu; Yu-Ming Huo; Hong-Hong Chang; Xing Li; Wen-Long Wei
• Keywords: Reaction conditions

A general method for the synthesis of oxazolines and oxazoles was developed through I2-catalyzed C–O bond formation dehydrogenation with same oxidant, TBHP. By simply tuning reaction bases, either or were selectively produced from β-acylamino ketones.