Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions

• DOI: 10.1021/acs.orglett.5b01997
• Publication Date: 2015-08-20T12:35:02Z
• Authors: Qiao Chen; Jiawei Zhou; Yanan Wang; Chao Wang; Xihong Liu; Zhaoqing Xu; Li Lin; Rui Wang
• Keywords: Hydrocarbons, Fluorinated; Molecular Structure; Tetrahydroisoquinolines; Acetamides; Combinatorial Chemistry Techniques; 01 natural sciences; 0104 chemical sciences

AbstractA scalable and efficient α,α‐difluoroamidation, carboxylation, and phosphorylation of various N‐aryltetrahydroisoquinolines is described.