Automated Glycan Assembly of Oligosaccharides Related to Arabinogalactan Proteins

• DOI: 10.1021/acs.orglett.5b02185
• Publication Date: 2015-08-21T15:50:55Z
• Authors: Max P. Bartetzko; Frank Schuhmacher; Heung Sik Hahm; Peter H. Seeberger; Fabian Pfrengle
• Keywords: Arabinogalactan; Monosaccharide; Glycobiology

Arabinogalactan proteins are heavily glycosylated proteoglycans in plants. Their glycan portion consists of type-II arabinogalactan polysaccharides whose heterogeneity hampers the assignment protein function. Synthetic chemistry is key to procurement molecular probes for plant biologists. Described automated assembly 14 oligosaccharides from four monosaccharide building blocks. These linear and branched glycans represent structural features natural arabinogalactans will serve as tools biology.