N-Heterocyclic Carbene-Catalyzed Activation of Esters ofN-Hydroxyphthalimide: A Highly Enantioselective Route to Chiral Dihydropyridinones Bearing an All Carbon Quaternary Stereogenic Center

• DOI: 10.1021/acs.orglett.5b02527
• Publication Date: 2015-10-06T15:16:27Z
• Authors: Zhiming Zhang; Xiaofei Zeng; Danbo Xie; Dongdong Chen; Liyuan Ding; Anna Wang; Limin Yang; Guofu Zhong
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractThe [3 + 3]‐cyclization reaction of N‐hydroxyphthalimide acrylates with N‐tosyl ketimines proceeds in moderate to high yields and with excellent enantiomeric excess.