Transition-Metal-Free Multicomponent Benzannulation Reactions for the Construction of Polysubstituted Benzene Derivatives

• DOI: 10.1021/acs.orglett.5b02548
• Publication Date: 2015-10-16T19:25:22Z
• Authors: Wen-Ming Shu; Kai-Lu Zheng; Jun-Rui Ma; An-Xin Wu
• Keywords: Acetylenedicarboxylate; Benzene derivatives; Dimethyl acetylenedicarboxylate

A transition-metal-free multicomponent benzannulation reaction was developed from readily available ketones, nitro-olefins, and diester acetylenedicarboxylate. This approach provides a straightforward efficient way to construct polysubstituted benzene derivatives under mild conditions in high yields.