Merging Photoredox with Palladium Catalysis: Decarboxylative ortho-Acylation of Acetanilides with α-Oxocarboxylic Acids under Mild Reaction Conditions

• DOI: 10.1021/acs.orglett.5b03192
• Publication Date: 2015-12-08T17:58:53Z
• Authors: Chao Zhou; Pinhua Li; Xianjin Zhu; Lei Wang
• Keywords: Acetanilide; Functional group; Eosin Y; Decarboxylation

A room temperature decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids has been developed via a novel Eosin Y Pd dual catalytic system. This reaction shows broad substrate scope and good functional group tolerance, an array ortho-acylacetanilides can be afforded in high yields under mild conditions.