Photocatalytic Pyridyl-carbamoylation of Alkenes for Accessing β-Pyridyl Amides

• DOI: 10.1021/acs.orglett.5c00195
• Publication Date: 2025-03-07T16:47:11Z
• Authors: Cui Jian; Zhikai Li; Yuyuan Mao; Yilin Zhu; Weijie Yu; Jie Wu; Shaoyu Li

The β-pyridyl amide is a critical scaffold in medical discovery yet lacks efficient synthetic methods. Here, we describe, for the first time, visible-light-induced, redox-neutral radical cross-coupling reaction involving alkenes, oxamic acids, and cyanopyridines that offers versatile assembly of β-pyridylamides. This approach features mild conditions, high step efficiency, substrate breadth, providing green strategy alkene pyridyl-carbamoylation. Achieving this transformation relies on catalytic system, which adeptly avoids competing nucleophilic carbamoyl with electrophilic pyridyl radical, enabling three-component tandem process chemoselectivity.