Copper-Catalyzed Regioselective 1,4-Sulfonyl Indolylation of 1,3-Dienes with Sulfonyl Chloride and Indoles

• DOI: 10.1021/acs.orglett.5c00245
• Publication Date: 2025-02-22T16:50:21Z
• Authors: Pu Chen; Lin Tian; Xiaochen Ji; Guo-Jun Deng; Huawen Huang
• Keywords: Sulfonyl

A copper-based catalytic system has been described to enable the efficient 1,4-sulfonylindolylation of 1,3-dienes with sulfonyl chloride and indoles. This protocol offers a practical method for synthesis allylsulfone-containing indole derivatives broad range compatible functionalities excellent chemo- regioselectivities. Mechanistic studies suggest that copper catalyst plays dual role initiating radicals prompting coupling in this conjugated diene-selective 1,4-difunctionalization strategy.