Photoredox/Copper Dual-Catalyzed Three-Component Perfluoroalkyl Trifluoromethylthiolation of Alkenes

• DOI: 10.1021/acs.orglett.5c00289
• Publication Date: 2025-02-20T11:10:16Z
• Authors: Kang Guo; Shaomian Liu; Yutong Yang; Fang Xu; Yongchao Lu; Jiayi Shang; Aizhen Song
• Keywords: Component (thermodynamics)

A new three-component 1,2-perfluoroalkyl trifluoromethylthiolation of alkenes via dual photoredox/copper catalysis has been established, affording a variety CnF2n+1/CF3S-containing molecules under mild conditions in redox-neutral manner. This protocol exhibits excellent functional group tolerance, broad compatibility with various and perfluoroalkyl iodides, potential utility the modification bioactive molecules.