Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010

• DOI: 10.1021/acs.orglett.6b00336
• Publication Date: 2016-03-03T13:40:24Z
• Authors: Zhaoming Liu; Yan Chen; Senhua Chen; Yayue Liu; Yongjun Lu; Dongni Chen; Yongcheng Lin; Xishan Huang; Zhigang She
• Keywords: Aspergillus terreus; Carbon skeleton

Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures elucidated on basis spectroscopic methods, single-crystal X-ray diffraction analysis, electronic circular dichroism calculations. biogenetic pathway for 1 2 is proposed. Both showed no significant antibacterial activity or cytotoxicity at 50 μM.