Tuning of Copper-Catalyzed Multicomponent Reactions toward 3-Functionalized Oxindoles

• DOI: 10.1021/acs.orglett.6b00964
• Publication Date: 2016-05-05T13:37:56Z
• Authors: Dong Cheng; Fei Ling; Chenguang Zheng; Cheng Ma
• Keywords: 01 natural sciences; 0104 chemical sciences

A tunable copper-catalyzed azide–alkyne cycloaddition (CuAAC)-initiated multicomponent reaction strategy for the construction of 3-functionalized indolin-2-ones is reported. Upon controlling ring opening four-membered O-heterocyclic intermediates, this unique method enables divergent derivatization N-protected isatins to give three-component (3-CR) and four-component (4-CR) adducts, respectively.