Meroterpenoids with New Skeletons from Myrtus communis and Structure Revision of Myrtucommulone K

• DOI: 10.1021/acs.orglett.6b01817
• Publication Date: 2016-07-29T13:03:29Z
• Authors: Chao Liu; Song Ang; Xiao-Jun Huang; Hai-Yan Tian; Yuan-Yuan Deng; Dong-Mei Zhang; Ying Wang; Wen-Cai Ye; Lei Wang
• Keywords: Undecane; Myrtus communis; Terpene; Carbon skeleton

Five sesquiterpene-based meroterpenoids with three kinds of new skeletons [1, 2, 3, (+)-4, and (−)-4] were isolated from the leaves Myrtus communis. Compound 1 featured a carbon skeleton an unprecedented octahydrospiro[bicyclo[7.2.0]undecane-2,2′-chromene] tetracyclic ring system, which possessed two preferred conformations detected by variable-temperature NMR spectroscopy experiments. In addition, structure reported myrtucommulone K was revised to be compound 3. The plausible biosynthetic pathways these their cytotoxicities are discussed.