Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones

• DOI: 10.1021/acs.orglett.6b02609
• Publication Date: 2016-09-30T20:19:07Z
• Authors: Gongming Zhu; Guangjun Bao; Yiping Li; Junxian Yang; Wangsheng Sun; Jing Li; Liang Hong; Rui Wang
• Keywords: Moiety; Phosphoric acid; Benzofuran

A highly enantioselective oxidative dearomatization of naphthols with quinones catalyzed by a chiral spirocyclic phosphoric acid is described. The strategy provides concise access to enantioenriched cyclohexadienones quinone moiety. Remarkably, the obtained products could be easily transformed potentially useful dihydronaphtho[2,1-b]benzofuran scaffold.