Selesconol, a Fungal Polyketide That Induces Stem Cell Differentiation

• DOI: 10.1021/acs.orglett.6b02688
• Publication Date: 2016-10-14T12:10:48Z
• Authors: Ai Hua Zhang; Rui Tan; Nan Jiang; Kaidiriye Yusupu; Gang Wang; Xin Lei Wang; Ren Xiang Tan
• Keywords: Inducer

Owing to the negligible or acceptable immunogenicity, small molecules capable of inducing differentiation undifferentiated stem cells into organ-specific cell types are particularly promising in developing replacement therapy, but such compounds with undescribed architectures extremely rare. Selesconol (1) is discovered from culture Daldinia eschscholzii IFB-TL01 as a skeletally unprecedented inducer for rat bone marrow mesenchymal neural cells, its unique framework clarified derive intermediate tautomerization dalesconol A biosynthetic pathway.