Direct α-Arylation/Heteroarylation of 2-Trifluoroboratochromanones via Photoredox/Nickel Dual Catalysis

• DOI: 10.1021/acs.orglett.6b03448
• Publication Date: 2017-01-12T12:25:53Z
• Authors: Jennifer K. Matsui; Gary A. Molander
• Keywords: Photoredox catalysis; Dual role

Utilizing photoredox/nickel dual catalysis, diverse flavanones have been synthesized by coupling novel 2-trifluoroboratochromanone building blocks with aryl and heteroaryl bromide partners. The newly reported trifluoroboratochromanones can be easily accessed from the corresponding chromones on multigram scale. This represents a general route for accessing natural unnatural that were previously formed through synthetically more restrictive ring closure chalcone precursors.