Palladium-Catalyzed Direct Intramolecular C–N Bond Formation: Access to Multisubstituted Dihydropyrroles

• DOI: 10.1021/acs.orglett.7b00072
• Publication Date: 2017-02-09T13:36:38Z
• Authors: Bing Jiang; Fei-Fan Meng; Qiu-Ju Liang; Yun-He Xu; Teck-Peng Loh
• Keywords: 01 natural sciences; 0104 chemical sciences

A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.