Synthesis of Substituted Cyclopropanecarboxylates via Room Temperature Palladium-Catalyzed α-Arylation of Reformatsky Reagents

• DOI: 10.1021/acs.orglett.7b00707
• Publication Date: 2017-05-01T20:40:54Z
• Authors: Stephen N. Greszler; Geoff T. Halvorsen; Eric A. Voight
• Keywords: 01 natural sciences; 0104 chemical sciences

The room temperature palladium-catalyzed cross-coupling of aromatic and heteroaromatic halides with Reformatsky reagents derived from 1-bromocyclopropanecarboxylates provides an exceptionally mild method for enolate α-arylation. is tolerant a wide range functionalities dramatically shortens many the existing routes to access widely used 1,1-disubstituted cyclopropanecarboxylate derivatives.