Cu-Catalyzed Stereoselective Borylation of gem-Difluoroalkenes with B2pin2

• DOI: 10.1021/acs.orglett.7b01430
• Publication Date: 2017-06-05T19:44:57Z
• Authors: Juan Zhang; Wenpeng Dai; Qingyun Liu; Song Cao
• Keywords: 01 natural sciences; 0104 chemical sciences

A novel and efficient method for the synthesis of (Z)-fluorinated alkenylboronic acid pinacol esters via Cu-catalyzed stereoselective borylation of gem-difluoroalkenes using bis(pinacolato)diboron (B2pin2) as the boron source with the assistance of NaOtBu and Xantphos at room temperature was developed.