Pd-Catalyzed Desulfonative Cross-Coupling of Benzylic Sulfone Derivatives with 1,3-Oxazoles

• DOI: 10.1021/acs.orglett.7b01510
• Publication Date: 2017-06-30T19:23:59Z
• Authors: Jacky C.-H. Yim; Masakazu Nambo; Cathleen M. Crudden
• Keywords: Sulfone; Oxazole; Scope (computer science)

The Pd-catalyzed desulfonative cross-coupling reaction of benzylic sulfone derivatives with 1,3-oxazoles via a deprotonative pathway has been developed. Broad substrate scope for both and 1,3-oxazole partners is observed, affording variety 1,3-oxazole-containing triarylmethanes. Sulfone that are primary benzylic, secondary benzhydryl all effective. Using this method, the straightforward synthesis multiply arylated structures demonstrated.