Enantioselective [3 + 2] Annulation of Enals with 2-Aminoacrylates Catalyzed by N-Heterocyclic Carbene

• DOI: 10.1021/acs.orglett.7b01860
• Publication Date: 2017-07-13T12:49:00Z
• Authors: Xing-Shuo Li; Liang-Liang Zhao; Xiao-Ke Wang; Li−Li Cao; Xiao-Qian Shi; Rui Zhang; Jing Qi
• Keywords: Annulation; Stereocenter; Quaternary carbon; Lactam

A novel and convenient strategy for the enantioselective synthesis of γ-lactam derivatives via N-heterocyclic carbene catalyzed formal [3 + 2] annulation enals with 2-aminoacrylates is disclosed. This activation mode provides a complementary approach to various in good yields excellent diastereo- enantioselectivities. In this process, two consecutive stereocenters are constructed, quaternary carbon center also established.