Development of Biligands Magnesium Catalysis in Asymmetric Conjugate Reactions of C3-Pyrrolyl-Oxindoles

• DOI: 10.1021/acs.orglett.7b02044
• Publication Date: 2017-07-28T12:49:13Z
• Authors: Kezhou Wang; Linqing Wang; Xihong Liu; Dan Li; Haiyong Zhu; Pengxin Wang; Yuyang Liu; Dongxu Yang; Rui Wang
• Keywords: Oxindole; Conjugate

A magnesium catalyzed asymmetric conjugate reaction of C3-pyrrolyl-oxindoles with terminal alkynones is presented. The current relies on the development novel combinational catalysis involving two chiral ligands. protocol proceeds smoothly and gives corresponding enantioenriched 3,3-disubstituted oxindole skeletons good enantioselectivities. Furthermore, adducts could be transferred to spiro structures containing an eight-membered ring in high ee values.