Pd-Catalyzed Thiophene–Aryl Coupling Reaction via C–H Bond Activation in Deep Eutectic Solvents

• DOI: 10.1021/acs.orglett.7b02114
• Publication Date: 2017-09-06T22:17:21Z
• Authors: Angela Punzi; Donato I. Coppi; Sergio Matera; Maria A. M. Capozzi; Alessandra Operam...; Roberta Ragni; Francesco Babudri; Gianluca M. Farinola
• Keywords: Choline chloride; Deep eutectic solvent; Anhydrous

Direct arylation of 5-octylthieno[3,4-c]pyrrole-4,6-dione with a series functionalized aryl iodides via C–H bond activation is demonstrated in deep eutectic solvent made choline chloride and urea non-anhydrous conditions without exclusion air. This the first demonstration thiophene–aryl coupling direct solvents.