Rhodium(III)-Catalyzed Oxidative Cross-Coupling of Unreactive C(sp3)–H Bonds with C(sp2)–H Bonds

• DOI: 10.1021/acs.orglett.7b02167
• Publication Date: 2017-08-30T12:51:28Z
• Authors: Guangying Tan; Jingsong You
• Keywords: Coupling reaction

The development of the oxidative cross-coupling unreactive C(sp3)-H bonds with (hetero)arene C(sp2)-H is considerably appealing, yet conceptually and practically challenging. Here, we disclose rhodium-catalyzed heteroarylation unactivated heteroarene bonds. This method provides a step-economic route to β-heteroarylated 2-ethylpyridine derivatives, which exhibits relatively broad substrate scope, high tolerance level sensitive functional groups, selectivity. protocol can also be extended coupling reaction between 8-methylquinoline derivatives heteroarenes.