Copper-Catalyzed C(sp2)–S Coupling Reactions for the Synthesis of Aryl Dithiocarbamates with Thiuram Disulfide Reagents

• DOI: 10.1021/acs.orglett.7b02911
• Publication Date: 2017-10-16T19:52:01Z
• Authors: Zhi-Bing Dong; Xing Liu; Carsten Bolm
• Keywords: 01 natural sciences; 0104 chemical sciences

An efficient protocol for the copper-catalyzed preparation of aryl dithiocarbamates from aryl iodides and inexpensive, environmentally benign tetraalkylthiuram disulfides was developed. The features of mild reaction conditions, high yields, and broad substrate scope render this new approach synthetically attractive for the preparation of potentially biologically active compounds.