Synthesis of Oligosaccharide Components of the Outer Core Domain of P. aeruginosa Lipopolysaccharide Using a Multifunctional Hydroquinone-Derived Reducing-End Capping Group

• DOI: 10.1021/acs.orglett.7b03590
• Publication Date: 2017-12-29T12:35:51Z
• Authors: Abhishek Vartak; Fatma M. Hefny; Steven J. Sucheck
• Keywords: Hydroquinone; Glycoconjugate; Oligosaccharide; Trisaccharide

The synthesis of a trisaccharide (common to glycoform I and II) tetrasaccharide I) from the outer core domain Pseudomonas aeruginosa lipopolysaccharide (LPS) using novel hydroquinone-based reducing-end capping group is reported. This multifunctional was utilized as purification handle stable toward many common transformations in oligosaccharide synthesis. access outer-core LPS antigens with TBDPS-protected hydroquinone (TPH) at reducing end will be useful for glycan array therapeutic glycoconjugate