[Copper(I)(Pyridine-Containing Ligand)] Catalyzed Regio- and Steroselective Synthesis of 2-Vinylcyclopropa[b]indolines from 2-Vinylindoles

• DOI: 10.1021/acs.orglett.7b03704
• Publication Date: 2018-01-10T15:20:14Z
• Authors: Valentina Pirovano; Elisa Brambilla; Giorgio Tseberlidis
• Keywords: Asymmetric cyclopropanation; stereoselective-synthesis; ethyl diazoacetate; CU(I) complexes; enantioselective synthesis; copper; indoles; heterocycles; derivatives; SILICA; 01 natural sciences; 0104 chemical sciences

A [copper(I)pyridine-containing ligand]-catalyzed reaction between 2-vinylindoles and diazo esters is described. The reaction allows for the synthesis of a series of 2-vinylcyclopropa[b]indolines with excellent levels of regio- and sterocontrol under mild conditions.