Hydrogen-Bonded Duplexes with Lengthened Linkers

• DOI: 10.1021/acs.orglett.8b00283
• Publication Date: 2018-03-06T13:20:21Z
• Authors: Yukun Zhang; Ruikai Cao; Jie Shen; Cadnel S. F. Detchou; Yulong Zhong; Heng Wang; Sheng Zou; Qingfei Huang; Chunxia Lian; Qiwei Wang; Jin Zhu; Bing Gong
• Keywords: 01 natural sciences; 0104 chemical sciences

Connecting basic hydrogen-bonding units with lengthened flexible or rigid linkers generates oligoamide strands that carry new H-bonding sequences and association specificity, leading to H-bonded homo- heteroduplexes constants in the 104 M–1 range chloroform. Computational experimental studies indicate duplexes aromatic adopt bent conformations allow formation of interstrand H-bonds accommodate introduced liners, offering a series units.