Transition-Metal-Free Cleavage of C–C Triple Bonds in Aromatic Alkynes with S8 and Amides Leading to Aryl Thioamides

• DOI: 10.1021/acs.orglett.8b00573
• Publication Date: 2018-03-30T13:43:43Z
• Authors: Kai Xu; Ziyi Li; Fangyuan Cheng; Zhenzhen Zuo; Tao Wang; Mincan Wang; Lantao Liu
• Keywords: Triple bond; Cleavage (geology); Bond cleavage

A novel transition-metal-free cleavage reaction of C–C triple bonds in aromatic alkynes with S8 and amides furnishes aryl thioamides moderate to excellent yields. The remarkable features this thioamidation include the metal-free bond, mild conditions, as well wide substrate scope that is particularly compatible some internal acetamides.