Ru(II)-Catalyzed C–H Activation and Annulation Reaction via Carbon–Carbon Triple Bond Cleavage

• DOI: 10.1021/acs.orglett.8b00643
• Publication Date: 2018-04-06T14:07:11Z
• Authors: Rashmi Prakash; Bidisha R. Bora; Romesh C. Boruah; Sanjib Gogoi
• Keywords: Annulation; Triple bond; Cleavage (geology); Bond cleavage; Reinforced carbon–carbon; Carbon fibers

An unprecedented Ru(II)-catalyzed C–H activation and annulation reaction, which proceeds via C–C triple bond cleavage, is reported. This reaction of 2-phenyldihydrophthalazinediones with alkynes, works most efficiently in the presence bidented ligand 1,3-bis(diphenylphosphino)propane, affords good yields substituted quinazolines.