Copper(I)-Catalyzed Three-Component Click/Persulfuration Cascade: Regioselective Synthesis of Triazole Disulfides

• DOI: 10.1021/acs.orglett.8b01002
• Publication Date: 2018-05-08T14:59:38Z
• Authors: Weiguo Wang; Yunzhi Lin; Yudao Ma; Chen-Ho Tung; Zhenghu Xu
• Keywords: Triazole; Cascade reaction

A copper(I)-catalyzed three-component CuAAC/persulfuration reaction providing rapid access to asymmetric triazole disulfides has been developed. The interrupted click shows broad substrate scope, complete regioselectivity, and excellent functional group tolerability.