Dysiarenone, a Dimeric C21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria

• DOI: 10.1021/acs.orglett.8b01148
• Publication Date: 2018-05-09T14:55:38Z
• Authors: Wei-Hua Jiao; Bao-Hui Cheng; Guo-Dong Chen; Guo-Hua Shi; Jing Li; Tian-Yong Hu; Hou-Wen Lin
• Keywords: Sponge

Dysiarenone (1), a dimeric C21 meroterpenoid featuring an unprecedented 2-oxaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane] carbon skeleton, was isolated from the marine sponge Dysidea arenaria. The structure of 1 determined by HRMS and NMR spectroscopic analyses coupled with ECD calculations. showed inhibitory activities against COX-2 expression production prostaglandin E2 IC50 value 6.4 μM in LPS-stimulated RAW264.7 macrophages.