Copper-Mediated Aminoazidation, Aminohalogenation, and Aminothiocyanation of β,γ-Unsaturated Hydrazones: Synthesis of Versatile Functionalized Pyrazolines

• DOI: 10.1021/acs.orglett.8b01620
• Publication Date: 2018-07-16T19:21:50Z
• Authors: Li-Jing Wang; Pei-Xing Ren; Lin Qi; Manman Chen; Yan-Lei Lu; Jing-Ye Zhao; Rui Liu; Jia-Min Chen; Wei Li
• Keywords: Pyrazoline; Scope (computer science)

A versatile method for the rapid synthesis of diverse functionalized pyrazolines has been developed based on copper-mediated aminofunctionalization β,γ-unsaturated hydrazones. The scope this strategy encompasses a range difunctionalization reactions: aminoazidation, aminohalogenation, and aminothiocyanation. These reactions provide straightforward access to series useful pyrazoline building blocks containing various functional groups that are hard traditionally.