Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes

• DOI: 10.1021/acs.orglett.8b02451
• Publication Date: 2018-08-27T15:36:58Z
• Authors: Shuai Liu; Yangen Huang; Feng-Ling Qing; Xiu-Hua Xu
• Keywords: Decarboxylation; Base (topology)

The direct synthesis of C(CF3)Me2-substituted heteroarenes by decarboxylative 1,1-dimethyltrifluoroethylation with 3,3,3-trifluoro-2,2-dimethylpropanoic acid is reported. This method does not need the transition-metal catalyst, and base crucial for this reaction. A series previously unknown C(CF3)Me2-containing were obtained in high yields have potential applications drug discovery process.