A Photocatalyzed Cascade Approach Toward the Tetracyclic Core of Akuammiline Alkaloids

• DOI: 10.1021/acs.orglett.8b03648
• Publication Date: 2019-01-14T16:50:34Z
• Authors: Qile Wang; Jie Hu; Nan Zheng
• Keywords: Carbocation; Modularity; Substitution (logic); Cascade reaction

A cascade approach toward the tetracyclic core of akuammiline alkaloids which features high modularity and convergence is reported. Distinct substitution pattern can be readily introduced to by varying three building blocks with similar complexity. The critical event in a regio- stereoselective 1,2-shift enabled carbocation that sets up core.