Asymmetric Total Synthesis of (+)-Strychnine

• DOI: 10.1021/acs.orglett.8b03686
• Publication Date: 2018-12-18T13:07:13Z
• Authors: Liping He; Xiaobei Wang; Xiaoqing Wu; Zhaoxiang Meng; Xin Peng; Xiao-Yu Liu; Yong Qin
• Keywords: Strychnos; Chirality

A synthetic strategy for the catalytic asymmetric total synthesis of (+)-strychnine is disclosed. Key features this include an organocatalytic enantioselective Michael addition to establish chirality starting building block, a photoinduced radical cascade reaction access Corynanthe alkaloid intermediate, and bioinspired rearrangement generate core Strychnos alkaloids.