Cytorhizins A–D, Four Highly Structure-Combined Benzophenones from the Endophytic Fungus Cytospora rhizophorae

• DOI: 10.1021/acs.orglett.8b04107
• Publication Date: 2019-02-06T17:25:46Z
• Authors: Hongxin Liu; Haibo Tan; Yuchan Chen; Xueying Guo; Wenxuan Wang; Heng Guo; Zhaoming Liu; Weimin Zhang
• Keywords: Models, Molecular; Staphylococcus aureus; Molecular Structure; Antineoplastic Agents; Microbial Sensitivity Tests; Crystallography, X-Ray; 01 natural sciences; Anti-Bacterial Agents; 0104 chemical sciences; Benzophenones; Ascomycota; Cell Line, Tumor; Polyketides; Escherichia coli; Humans; Drug Screening Assays, Antitumor; Cell Proliferation

Cytorhizins A–D, four novel polyketide heterodimers, were isolated from the endophytic fungus Cytospora rhizophorae A761. These new compounds shared an unprecedented 6/6/5/6/8 or 6/6/5/6/7 pentacyclic ring system and fused as a fascinating cagelike skeleton, embodying by polyoxygenated isopentyl unit highly structure-combined benzophenone scaffold. Their structures elucidated extensive spectroscopic analyses X-ray diffraction techniques. Moreover, 1–4 evaluated for in vitro cytotoxicity antimicrobial activity.