Nickel-Catalyzed Intramolecular Direct Arylation of Imines toward Diverse Indoles

• DOI: 10.1021/acs.orglett.9b00600
• Publication Date: 2019-04-18T17:29:31Z
• Authors: Han Long; Kunhua Xu; Shanshan Chen; Jin Lin; Dan Wu; Bo Wu; Xu Tian; Lutz Ackermann
• Keywords: 01 natural sciences; 0104 chemical sciences

An efficient nickel-catalyzed intramolecular direct arylation of imines with challenging aryl chlorides has been developed. The versatile nickel catalysis made use of easily accessible imines and delivered diversely decorated 2-arylindoles of considerable importance to biological and medicinal chemistry.