Sodium Methyl Carbonate as an Effective C1 Synthon. Synthesis of Carboxylic Acids, Benzophenones, and Unsymmetrical Ketones

• DOI: 10.1021/acs.orglett.9b00773
• Publication Date: 2019-05-24T17:09:56Z
• Authors: Timothy E. Hurst; Julie A. Deichert; Lucas Kapeniak; Roland Lee; Jesse Harris; Philip G. Jessop; Victor Snieckus
• Keywords: Synthon; Reactivity; Sodium carbonate

Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting differential reactivity sodium methyl carbonate Grignard organolithium reagents.