A Pore-Forming Tripeptide as an Extraordinarily Active Anion Channel

• DOI: 10.1021/acs.orglett.9b01723
• Publication Date: 2019-06-13T13:06:27Z
• Authors: Fei Zeng; Fang Liu; Lin Yuan; Shaoyuan Zhou; Jie Shen; Ning Li; Haisheng Ren; Huaqiang Zeng
• Keywords: Tripeptide; Molar ratio

Compared to the most active anion-transporting channel that requires a channel:lipid molar ratio of 1:330 (0.3 mol % relative lipid) achieve 50% activity, structurally simple pore-forming tripeptide 6L310 was found exhibit an extraordinarily strong ability self-assemble into stable possibly barrel-shaped exceptionally channels, with record-low EC50 values 4.0, 3.0, 1.6, 2.6, and 2.6 nM (e.g., 0.005–0.013 for Cl–, Br–, I–, NO3–, ClO4–, respectively.