Arylation of Aldehydes To Directly Form Ketones via Tandem Nickel Catalysis

• DOI: 10.1021/acs.orglett.9b01782
• Publication Date: 2019-07-16T18:12:56Z
• Authors: Chuanhu Lei; Daoyong Zhu; Vicente III Tiu T...; Jianrong Steve Zhou
• Keywords: Tandem; Stereocenter

A nickel-catalyzed arylation of both aliphatic and aromatic aldehydes proceeds with air-stable (hetero)arylboronic acids, an exceptionally wide substrate scope. The neutral condition tolerates acidic hydrogen sensitive polar groups also preserves α-stereocenters some chiral aldehydes. Interestingly, this nickel(0) catalysis does not follow common 1,2-insertion arylmetal species to β-hydrogen elimination.